3UIX
Crystal structure of Pim1 kinase in complex with small molecule inhibitor
Summary for 3UIX
Entry DOI | 10.2210/pdb3uix/pdb |
Descriptor | Proto-oncogene serine/threonine-protein kinase pim-1, 2-{4-[(3-aminopropyl)amino]quinazolin-2-yl}phenol, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | pim-1, leukemia cell lethality, substrate-peptide-binding residue, fluorescent correlation spectroscopy, inhibitor complex, in silico screening, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 1 |
Total formula weight | 34781.22 |
Authors | Parker, L.J. (deposition date: 2011-11-06, release date: 2012-04-11, Last modification date: 2023-11-01) |
Primary citation | Tsuganezawa, K.,Watanabe, H.,Parker, L.,Yuki, H.,Taruya, S.,Nakagawa, Y.,Kamei, D.,Mori, M.,Ogawa, N.,Tomabechi, Y.,Handa, N.,Honma, T.,Yokoyama, S.,Kojima, H.,Okabe, T.,Nagano, T.,Tanaka, A. A novel pim-1 kinase inhibitor targeting residues that bind the substrate Peptide. J.Mol.Biol., 417:240-252, 2012 Cited by PubMed: 22306408DOI: 10.1016/j.jmb.2012.01.036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)