3UI7
Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia
Summary for 3UI7
Entry DOI | 10.2210/pdb3ui7/pdb |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 6-methoxy-3,8-dimethyl-4-(morpholin-4-ylmethyl)-1H-pyrazolo[3,4-b]quinoline, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | inhibitor complex, hydrolase, zn binding, mg binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 78021.10 |
Authors | Yang, S.,Smotryski, J.,Mcelroy, W.,Ho, G.,Tulshian, D.,Greenlee, W.J.,Hodgson, R.,Xiao, L.,Hruza, A. (deposition date: 2011-11-04, release date: 2011-12-21, Last modification date: 2024-02-28) |
Primary citation | Yang, S.W.,Smotryski, J.,McElroy, W.T.,Tan, Z.,Ho, G.,Tulshian, D.,Greenlee, W.J.,Guzzi, M.,Zhang, X.,Mullins, D.,Xiao, L.,Hruza, A.,Chan, T.M.,Rindgen, D.,Bleickardt, C.,Hodgson, R. Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia. Bioorg.Med.Chem.Lett., 22:235-239, 2012 Cited by PubMed: 22142545DOI: 10.1016/j.bmcl.2011.11.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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