3UH1

Crystal Structure of Saccharopine Dehydrogenase from Saccharomyces cerevisiae with bound saccharopine and NADH

Summary for 3UH1

Entry DOI	10.2210/pdb3uh1/pdb
Descriptor	Saccharopine dehydrogenase [NAD+, L-lysine-forming], 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, N-(5-AMINO-5-CARBOXYPENTYL)GLUTAMIC ACID, ... (5 entities in total)
Functional Keywords	enzyme mechanisms, lysine biosynthesis, proton shuttle, saccharopine and nad binding, oxidoreductase
Biological source	Saccharomyces cerevisiae (Baker's yeast)
Cellular location	Cytoplasm: P38998
Total number of polymer chains	1
Total formula weight	42541.51
Authors	Kumar, V.P.,Thomas, L.M.,Bobyk, K.D.,Andi, B.,West, A.H.,Cook, P.F. (deposition date: 2011-11-03, release date: 2012-02-01, Last modification date: 2024-02-28)
Primary citation	Kumar, V.P.,Thomas, L.M.,Bobyk, K.D.,Andi, B.,Cook, P.F.,West, A.H. Evidence in Support of Lysine 77 and Histidine 96 as Acid-Base Catalytic Residues in Saccharopine Dehydrogenase from Saccharomyces cerevisiae. Biochemistry, 51:857-866, 2012 Cited by PubMed: 22243403 DOI: 10.1021/bi201808u PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.17 Å)

Structure validation