3UFR

Structure of rat nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(((E)-5-(3-fluorophenyl)pent-4-en-1-yl)oxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine

3UFR の概要

• エントリーDOI: 10.2210/pdb3ufr/pdb
• 関連するPDBエントリー: 3UFO 3UFP 3UFQ 3UFS 3UFT 3UFU 3UFV 3UFW
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase, inhibitor binding, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100234.92

構造登録者

Li, H.,Poulos, T.L. (登録日: 2011-11-01, 公開日: 2012-07-11, 最終更新日: 2023-09-13)

• 主引用文献: Huang, H.,Ji, H.,Li, H.,Jing, Q.,Labby, K.J.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations.; J.Am.Chem.Soc., 134:11559-11572, 2012; PubMed: 22731813; DOI: 10.1021/ja302269r

実験手法

X-RAY DIFFRACTION (2.097 Å)