3UDW

Crystal structure of the immunoreceptor TIGIT in complex with Poliovirus receptor (PVR/CD155/necl-5) D1 domain

Summary for 3UDW

Entry DOI	10.2210/pdb3udw/pdb
Descriptor	T cell immunoreceptor with Ig and ITIM domains, Poliovirus receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	pvr tigit igsf signal transduction immunology, igsf, cell surface receptor signalling, glycosylation, membrane protein, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	51017.23
Authors	Rouge, L.,Stengel, K.F.,Yin, J.P.,Bazan, F.J.,Wiesmann, C. (deposition date: 2011-10-28, release date: 2012-03-14, Last modification date: 2020-07-29)
Primary citation	Stengel, K.F.,Harden-Bowles, K.,Yu, X.,Rouge, L.,Yin, J.,Comps-Agrar, L.,Wiesmann, C.,Bazan, J.F.,Eaton, D.L.,Grogan, J.L. Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering. Proc.Natl.Acad.Sci.USA, 109:5399-5404, 2012 Cited by PubMed: 22421438 DOI: 10.1073/pnas.1120606109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.903 Å)

Structure validation