3UDE

Crystal structure of E. coli HPPK in complex with bisubstrate analogue inhibitor J1B

3UDE の概要

• エントリーDOI: 10.2210/pdb3ude/pdb
• 関連するPDBエントリー: 3UD5 3UDV
• 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-[1-(2-{[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}ethyl)piperidin-4-yl]-5'-thioadenosine, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: alpha beta, kinase, atp binding, pyrophosphoryl transfer, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18640.30

構造登録者

Shaw, G.,Shi, G.,Ji, X. (登録日: 2011-10-28, 公開日: 2012-01-04, 最終更新日: 2023-09-13)

• 主引用文献: Shi, G.,Shaw, G.,Liang, Y.H.,Subburaman, P.,Li, Y.,Wu, Y.,Yan, H.,Ji, X.; Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties.; Bioorg.Med.Chem., 20:47-57, 2012; PubMed: 22169600; DOI: 10.1016/j.bmc.2011.11.032

実験手法

X-RAY DIFFRACTION (1.881 Å)