3UBD
Structure of N-terminal domain of RSK2 kinase in complex with flavonoid glycoside SL0101
Summary for 3UBD
| Entry DOI | 10.2210/pdb3ubd/pdb |
| Descriptor | Ribosomal protein S6 kinase alpha-3, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 3,4-di-O-acetyl-6-deoxy-alpha-L-mannopyranoside (3 entities in total) |
| Functional Keywords | kinase-inhibitor complex, induced fit, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Mus musculus (mouse) |
| Cellular location | Nucleus : P18654 |
| Total number of polymer chains | 1 |
| Total formula weight | 35516.21 |
| Authors | Utepbergenov, D.,Derewenda, U.,Derewenda, Z.S. (deposition date: 2011-10-24, release date: 2012-09-05, Last modification date: 2023-09-13) |
| Primary citation | Utepbergenov, D.,Derewenda, U.,Olekhnovich, N.,Szukalska, G.,Banerjee, B.,Hilinski, M.K.,Lannigan, D.A.,Stukenberg, P.T.,Derewenda, Z.S. Insights into the Inhibition of the p90 Ribosomal S6 Kinase (RSK) by the Flavonol Glycoside SL0101 from the 1.5 A Crystal Structure of the N-Terminal Domain of RSK2 with Bound Inhibitor. Biochemistry, 51:6499-6510, 2012 Cited by PubMed: 22846040DOI: 10.1021/bi300620c PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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