3UBD

Structure of N-terminal domain of RSK2 kinase in complex with flavonoid glycoside SL0101

3UBD の概要

• エントリーDOI: 10.2210/pdb3ubd/pdb
• 分子名称: Ribosomal protein S6 kinase alpha-3, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 3,4-di-O-acetyl-6-deoxy-alpha-L-mannopyranoside (3 entities in total)
• 機能のキーワード: kinase-inhibitor complex, induced fit, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Nucleus : P18654
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35516.21

構造登録者

Utepbergenov, D.,Derewenda, U.,Derewenda, Z.S. (登録日: 2011-10-24, 公開日: 2012-09-05, 最終更新日: 2023-09-13)

• 主引用文献: Utepbergenov, D.,Derewenda, U.,Olekhnovich, N.,Szukalska, G.,Banerjee, B.,Hilinski, M.K.,Lannigan, D.A.,Stukenberg, P.T.,Derewenda, Z.S.; Insights into the Inhibition of the p90 Ribosomal S6 Kinase (RSK) by the Flavonol Glycoside SL0101 from the 1.5 A Crystal Structure of the N-Terminal Domain of RSK2 with Bound Inhibitor.; Biochemistry, 51:6499-6510, 2012; PubMed: 22846040; DOI: 10.1021/bi300620c

実験手法

X-RAY DIFFRACTION (1.53 Å)