3U6J
Crystal structure of the VEGFR2 kinase domain in complex with a pyrazolone inhibitor
Summary for 3U6J
Entry DOI | 10.2210/pdb3u6j/pdb |
Related | 3U6H 3U6I |
Descriptor | Vascular endothelial growth factor receptor 2, N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (3 entities in total) |
Functional Keywords | kdr, flk-1, angiogenesis, phosphotransferase, cancer, vascular endothelial growth factor, transferase/transferase inhibitor, transferase-transferase inhibitor complex |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted (Probable). Isoform 3: Secreted: P35968 |
Total number of polymer chains | 1 |
Total formula weight | 36685.23 |
Authors | Whittington, D.A.,Long, A.,Rose, P.,Gu, Y.,Zhao, H. (deposition date: 2011-10-12, release date: 2012-02-22, Last modification date: 2024-02-28) |
Primary citation | Norman, M.H.,Liu, L.,Lee, M.,Xi, N.,Fellows, I.,D'Angelo, N.D.,Dominguez, C.,Rex, K.,Bellon, S.F.,Kim, T.S.,Dussault, I. Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives. J.Med.Chem., 55:1858-1867, 2012 Cited by PubMed: 22320343DOI: 10.1021/jm201330u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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