3U6I

Crystal structure of c-Met in complex with pyrazolone inhibitor 58a

3U6I の概要

• エントリーDOI: 10.2210/pdb3u6i/pdb
• 関連するPDBエントリー: 3U6H 3U6J
• 分子名称: Hepatocyte growth factor receptor, N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}-1-[(2R)-2-hydroxypropyl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (3 entities in total)
• 機能のキーワード: kinase domain, phosphotransferase, cancer, hepatocyte growth factor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35758.27

構造登録者

Bellon, S.F.,Whittington, D.A.,Long, A.L. (登録日: 2011-10-12, 公開日: 2012-02-22, 最終更新日: 2023-09-13)

• 主引用文献: Norman, M.H.,Liu, L.,Lee, M.,Xi, N.,Fellows, I.,D'Angelo, N.D.,Dominguez, C.,Rex, K.,Bellon, S.F.,Kim, T.S.,Dussault, I.; Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives.; J.Med.Chem., 55:1858-1867, 2012; PubMed: 22320343; DOI: 10.1021/jm201330u

実験手法

X-RAY DIFFRACTION (2.1 Å)