3U4R
Novel HCV NS5B polymerase Inhibitors: Discovery of Indole C2 Acyl sulfonamides
3U4R の概要
エントリーDOI | 10.2210/pdb3u4r/pdb |
関連するPDBエントリー | 3U4O |
分子名称 | RNA-directed RNA polymerase, 1-[(2-aminopyridin-4-yl)methyl]-5-chloro-N-({3-[(methylsulfonyl)amino]phenyl}sulfonyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide (3 entities in total) |
機能のキーワード | nucleotidyl transfer, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Hepatitis C virus (HCV) |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): O92972 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 130189.99 |
構造登録者 | Anilkumar, G.N.,Selyutin, O.,Rosenblum, S.B.,Zeng, Q.,Jiang, Y.,Chan, T.-Y.,Pu, H.,Wang, L.,Bennett, F.,Chen, K.X.,Lesburg, C.A.,Duca, J.S.,Gavalas, S.,Huang, Y.,Pinto, P.,Sannagrahi, M.,Velazquez, F.,Venkataraman, S.,Vilbubhan, B.,Agrawal, S.,Ferrari, E.,Jiang, C.-K.,Huang, H.-C.,Shih, N.-Y.,Njoroge, F.G.,Kozlowski, J.A. (登録日: 2011-10-10, 公開日: 2011-12-07, 最終更新日: 2024-02-28) |
主引用文献 | Anilkumar, G.N.,Selyutin, O.,Rosenblum, S.B.,Zeng, Q.,Jiang, Y.,Chan, T.Y.,Pu, H.,Wang, L.,Bennett, F.,Chen, K.X.,Lesburg, C.A.,Duca, J.,Gavalas, S.,Huang, Y.,Pinto, P.,Sannigrahi, M.,Velazquez, F.,Venkatraman, S.,Vibulbhan, B.,Agrawal, S.,Ferrari, E.,Jiang, C.K.,Huang, H.C.,Shih, N.Y.,George Njoroge, F.,Kozlowski, J.A. II. Novel HCV NS5B polymerase inhibitors: Discovery of indole C2 acyl sulfonamides. Bioorg.Med.Chem.Lett., 22:713-717, 2012 Cited by PubMed: 22104146DOI: 10.1016/j.bmcl.2011.10.041 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
検証レポート(詳細版)
をダウンロード
![ダウンロード](/newweb/media/icons/dl.png)