3TZF

Crystal Structure of the Yersinia pestis Dihydropteroate Synthase with Sulfonamide Drug Complex.

Summary for 3TZF

• Entry DOI: 10.2210/pdb3tzf/pdb
• Related: 3TYU 3TYZ 3TZN
• Descriptor: 7,8-dihydropteroate synthase, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: dihydropteroate synthase, sulfonamide complex, tim barrel, transferase-inhibitor-antibiotic complex, transferase-antibiotic-inhibitor complex, transferase/antibiotic/inhibitor
• Biological source: Yersinia pestis
• Total number of polymer chains: 2
• Total formula weight: 61643.59

Authors

Wu, Y. (deposition date: 2011-09-27, release date: 2012-03-14, Last modification date: 2024-02-28)

• Primary citation: Yun, M.K.,Wu, Y.,Li, Z.,Zhao, Y.,Waddell, M.B.,Ferreira, A.M.,Lee, R.E.,Bashford, D.,White, S.W.; Catalysis and sulfa drug resistance in dihydropteroate synthase.; Science, 335:1110-1114, 2012; PubMed: 22383850; DOI: 10.1126/science.1214641

Experimental method

X-RAY DIFFRACTION (2.1 Å)