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3TV6

Human B-Raf Kinase Domain in Complex with a Methoxypyrazolopyridinyl Benzamide Inhibitor

Summary for 3TV6
Entry DOI10.2210/pdb3tv6/pdb
Related3TV4
DescriptorSerine/threonine-protein kinase B-raf, 2,6-difluoro-N-(3-methoxy-2H-pyrazolo[3,4-b]pyridin-5-yl)-3-[(propylsulfonyl)amino]benzamide (2 entities in total)
Functional Keywordsb-raf, kinase, kinase inhibitor, transferase, c-raf, ras, mek, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight71286.09
Authors
Voegtli, W.C.,Sturgis, H.L.,Wu, W.-I. (deposition date: 2011-09-19, release date: 2011-10-05, Last modification date: 2024-02-28)
Primary citationWenglowsky, S.,Ren, L.,Ahrendt, K.A.,Laird, E.R.,Aliagas, I.,Alicke, B.,Buckmelter, A.J.,Choo, E.F.,Dinkel, V.,Feng, B.,Gloor, S.L.,Gould, S.E.,Gross, S.,Gunzner-Toste, J.,Hansen, J.D.,Hatzivassiliou, G.,Liu, B.,Malesky, K.,Mathieu, S.,Newhouse, B.,Raddatz, N.J.,Ran, Y.,Rana, S.,Randolph, N.,Risom, T.,Rudolph, J.,Savage, S.,Selby, L.T.,Shrag, M.,Song, K.,Sturgis, H.L.,Voegtli, W.C.,Wen, Z.,Willis, B.S.,Woessner, R.D.,Wu, W.I.,Young, W.B.,Grina, J.
Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors.
ACS Med Chem Lett, 2:342-347, 2011
Cited by
PubMed: 24900315
DOI: 10.1021/ml200025q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.3 Å)
Structure validation

217705

數據於2024-03-27公開中

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