3TV6

Human B-Raf Kinase Domain in Complex with a Methoxypyrazolopyridinyl Benzamide Inhibitor

3TV6 の概要

• エントリーDOI: 10.2210/pdb3tv6/pdb
• 関連するPDBエントリー: 3TV4
• 分子名称: Serine/threonine-protein kinase B-raf, 2,6-difluoro-N-(3-methoxy-2H-pyrazolo[3,4-b]pyridin-5-yl)-3-[(propylsulfonyl)amino]benzamide (2 entities in total)
• 機能のキーワード: b-raf, kinase, kinase inhibitor, transferase, c-raf, ras, mek, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71286.09

構造登録者

Voegtli, W.C.,Sturgis, H.L.,Wu, W.-I. (登録日: 2011-09-19, 公開日: 2011-10-05, 最終更新日: 2024-02-28)

• 主引用文献: Wenglowsky, S.,Ren, L.,Ahrendt, K.A.,Laird, E.R.,Aliagas, I.,Alicke, B.,Buckmelter, A.J.,Choo, E.F.,Dinkel, V.,Feng, B.,Gloor, S.L.,Gould, S.E.,Gross, S.,Gunzner-Toste, J.,Hansen, J.D.,Hatzivassiliou, G.,Liu, B.,Malesky, K.,Mathieu, S.,Newhouse, B.,Raddatz, N.J.,Ran, Y.,Rana, S.,Randolph, N.,Risom, T.,Rudolph, J.,Savage, S.,Selby, L.T.,Shrag, M.,Song, K.,Sturgis, H.L.,Voegtli, W.C.,Wen, Z.,Willis, B.S.,Woessner, R.D.,Wu, W.I.,Young, W.B.,Grina, J.; Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors.; ACS Med Chem Lett, 2:342-347, 2011; PubMed: 24900315; DOI: 10.1021/ml200025q

実験手法

X-RAY DIFFRACTION (3.3 Å)