3TOH
HIV-1 Protease - Epoxydic Inhibitor Complex (pH 9 - Orthorombic Crystal form P212121)
Summary for 3TOH
Entry DOI | 10.2210/pdb3toh/pdb |
Related PRD ID | PRD_001019 |
Descriptor | Gag-Pol polyprotein, (S)-N-((2S,3S,4R,5R)-4-amino-3,5-dihydroxy-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-phenoxyacetamido)butanamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | hiv pr, epoxide, in-crystal reaction, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 (BRU ISOLATE) (HIV-1) |
Total number of polymer chains | 2 |
Total formula weight | 22249.41 |
Authors | Geremia, S.,Olajuyigbe, F.M.,Demitri, N. (deposition date: 2011-09-05, release date: 2012-08-15, Last modification date: 2023-09-13) |
Primary citation | Olajuyigbe, F.M.,Demitri, N.,De Zorzi, R.,Geremia, S. Developing HIV-1 Protease Inhibitors through Stereospecific Reactions in Protein Crystals. Molecules, 21:-, 2016 Cited by PubMed: 27809253DOI: 10.3390/molecules21111458 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.116 Å) |
Structure validation
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