3TNT
Crystal structure of SARS coronavirus main protease complexed with an alpha, beta-unsaturated ethyl ester inhibitor SG85
Summary for 3TNT
Entry DOI | 10.2210/pdb3tnt/pdb |
Descriptor | SARS coronavirus main protease, N-[(benzyloxy)carbonyl]-O-tert-butyl-L-seryl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide (3 entities in total) |
Functional Keywords | 3c-like protease, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | SARS coronavirus (SARS-CoV) |
Cellular location | Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8 |
Total number of polymer chains | 1 |
Total formula weight | 34529.42 |
Authors | Zhu, L.,Hilgenfeld, R. (deposition date: 2011-09-02, release date: 2012-09-05, Last modification date: 2017-11-08) |
Primary citation | Zhu, L.,Hilgenfeld, R. Crystal structures of SARS-Cov main protease complexed with a series of peptidic unsaturated esters To be Published, |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)