3TNT

Crystal structure of SARS coronavirus main protease complexed with an alpha, beta-unsaturated ethyl ester inhibitor SG85

3TNT の概要

• エントリーDOI: 10.2210/pdb3tnt/pdb
• 分子名称: SARS coronavirus main protease, N-[(benzyloxy)carbonyl]-O-tert-butyl-L-seryl-N-{(2R)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pentan-2-yl}-L-phenylalaninamide (3 entities in total)
• 機能のキーワード: 3c-like protease, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: SARS coronavirus (SARS-CoV)
• 細胞内の位置: Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34529.42

構造登録者

Zhu, L.,Hilgenfeld, R. (登録日: 2011-09-02, 公開日: 2012-09-05, 最終更新日: 2017-11-08)

• 主引用文献: Zhu, L.,Hilgenfeld, R.; Crystal structures of SARS-Cov main protease complexed with a series of peptidic unsaturated esters; To be Published,

実験手法

X-RAY DIFFRACTION (1.59 Å)