3TLH

STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITHAN EFFICIENT INHIBITOR OF FIV PR

Summary for 3TLH

• Entry DOI: 10.2210/pdb3tlh/pdb
• Related PRD ID: PRD_000434
• Descriptor: PROTEIN (PROTEASE), benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate (3 entities in total)
• Functional Keywords: hiv protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus type 1 (CLONE 12)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
• Total number of polymer chains: 1
• Total formula weight: 11713.89

Authors

Li, M.,Lee, T.,Morris, G.,Laco, G.,Wong, C.,Olson, A.,Elder, J.,Wlodawer, A.,Gustchina, A. (deposition date: 1998-12-03, release date: 1998-12-09, Last modification date: 2023-12-27)

• Primary citation: Li, M.,Morris, G.M.,Lee, T.,Laco, G.S.,Wong, C.H.,Olson, A.J.,Elder, J.H.,Wlodawer, A.,Gustchina, A.; Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease; Proteins, 38:29-40, 2000; PubMed: 10651036; DOI: 10.1002/(SICI)1097-0134(20000101)38:1<29::AID-PROT4>3.0.CO;2-N

Experimental method

X-RAY DIFFRACTION (2 Å)