3TLH
STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITHAN EFFICIENT INHIBITOR OF FIV PR
3TLH の概要
エントリーDOI | 10.2210/pdb3tlh/pdb |
関連するBIRD辞書のPRD_ID | PRD_000434 |
分子名称 | PROTEIN (PROTEASE), benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate (3 entities in total) |
機能のキーワード | hiv protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Human immunodeficiency virus type 1 (CLONE 12) |
細胞内の位置 | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 11713.89 |
構造登録者 | Li, M.,Lee, T.,Morris, G.,Laco, G.,Wong, C.,Olson, A.,Elder, J.,Wlodawer, A.,Gustchina, A. (登録日: 1998-12-03, 公開日: 1998-12-09, 最終更新日: 2023-12-27) |
主引用文献 | Li, M.,Morris, G.M.,Lee, T.,Laco, G.S.,Wong, C.H.,Olson, A.J.,Elder, J.H.,Wlodawer, A.,Gustchina, A. Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease Proteins, 38:29-40, 2000 Cited by PubMed: 10651036DOI: 10.1002/(SICI)1097-0134(20000101)38:1<29::AID-PROT4>3.0.CO;2-N 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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