3TKU

MRCK beta in complex with fasudil

Summary for 3TKU

• Entry DOI: 10.2210/pdb3tku/pdb
• Related: 3QFV
• Descriptor: Serine/threonine-protein kinase MRCK beta, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: protein kinase, serine threonine kinase, mrck, mrck beta, cd binding protein kinase beta, fasudil, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): Q9Y5S2
• Total number of polymer chains: 2
• Total formula weight: 101020.32

Authors

Heikkila, T.J.,Turnbull, A.,Wheatley, E.,Schroder, E.,Crighton, D.,Olson, M.F. (deposition date: 2011-08-29, release date: 2011-10-05, Last modification date: 2023-09-13)

• Primary citation: Heikkila, T.,Wheatley, E.,Crighton, D.,Schroder, E.,Boakes, A.,Kaye, S.J.,Mezna, M.,Pang, L.,Rushbrooke, M.,Turnbull, A.,Olson, M.F.; Co-crystal structures of inhibitors with MRCK, a key regulator of tumor cell invasion; Plos One, 6:e24825-e24825, 2011; PubMed: 21949762; DOI: 10.1371/journal.pone.0024825

Experimental method

X-RAY DIFFRACTION (2.15 Å)