3TK3

Cytochrome P450 2B4 mutant L437A in complex with 4-(4-chlorophenyl)imidazole

3TK3 の概要

• エントリーDOI: 10.2210/pdb3tk3/pdb
• 分子名称: Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 4-(4-CHLOROPHENYL)IMIDAZOLE, ... (4 entities in total)
• 機能のキーワード: p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, cyp 2b4, cyp lm2
• 由来する生物種: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 219688.44

構造登録者

Gay, S.C.,Jang, H.H.,Wilderman, P.R.,Zhang, Q.,Stout, C.D.,Halpert, J.R. (登録日: 2011-08-25, 公開日: 2011-11-16, 最終更新日: 2023-09-13)

• 主引用文献: Wilderman, P.R.,Gay, S.C.,Jang, H.H.,Zhang, Q.,Stout, C.D.,Halpert, J.R.; Investigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzyme.; Febs J., 279:1607-1620, 2012; PubMed: 22051155; DOI: 10.1111/j.1742-4658.2011.08411.x

実験手法

X-RAY DIFFRACTION (2.8001 Å)