3TIU

Crystal structure of SARS coronavirus main protease complexed with an alpha,beta-unsaturated ethyl ester inhibitor SG82

3TIU の概要

• エントリーDOI: 10.2210/pdb3tiu/pdb
• 分子名称: SARS coronavirus main protease, DIMETHYL SULFOXIDE, ETHYL (5S,8S,11R)-8-BENZYL-5-(3-TERT-BUTOXY-3-OXOPROPYL)-3,6,9-TRIOXO-11-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}-1-PHENYL-2-OXA-4,7,10-TRIAZATETRADECAN-14-OATE, ... (4 entities in total)
• 機能のキーワード: coronavirus main protease, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: SARS coronavirus (SARS-CoV)
• 細胞内の位置: Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34649.58

構造登録者

Zhu, L.,Hilgenfeld, R. (登録日: 2011-08-22, 公開日: 2012-08-22, 最終更新日: 2024-10-30)

• 主引用文献: Zhu, L.,Hilgenfeld, R.; Crystal structures of SARS-Cov main protease complexed with a series of peptidic unsaturated esters; To be Published,

実験手法

X-RAY DIFFRACTION (2.08 Å)