3TH8

Structure of E. coli undecaprenyl diphosphate synthase complexed with BPH-1063

3TH8 の概要

• エントリーDOI: 10.2210/pdb3th8/pdb
• 分子名称: Undecaprenyl pyrophosphate synthase, (2Z)-4-({3-[3-(hexyloxy)phenyl]propyl}amino)-2-hydroxy-4-oxobut-2-enoic acid (3 entities in total)
• 機能のキーワード: all helices, prenyl transferase, farneyl diphosphate binding, isopentenyl diphosphate binding, prenylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57311.68

構造登録者

Cao, R.,Zhu, W.,Zhang, Y.,Oldfield, E. (登録日: 2011-08-18, 公開日: 2012-07-04, 最終更新日: 2023-09-13)

• 主引用文献: Zhang, Y.,Lin, F.-Y.,Li, K.,Zhu, W.,Liu, Y.L.,Cao, R.,Pang, R.,Lee, E.,Axelson, J.,Hensler, M.,Wang, K.,Molohon, K.J.,Wang, Y.,Mitchell, D.A.,Nizet, V.,Oldfield, E.; HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.; ACS Med Chem Lett, 3:402-406, 2012; PubMed: 22662288; DOI: 10.1021/ml300038t

実験手法

X-RAY DIFFRACTION (2.114 Å)