3TGG
A novel series of potent and selective PDE5 inhibitor2
Summary for 3TGG
Entry DOI | 10.2210/pdb3tgg/pdb |
Related | 3TGE |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 38141.45 |
Authors | |
Primary citation | Hughes, R.O.,Maddux, T.,Joseph Rogier, D.,Lu, S.,Walker, J.K.,Jon Jacobsen, E.,Rumsey, J.M.,Zheng, Y.,Macinnes, A.,Bond, B.R.,Han, S. Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region. Bioorg.Med.Chem.Lett., 21:6348-6352, 2011 Cited by PubMed: 21955943DOI: 10.1016/j.bmcl.2011.08.106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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