3T4R

Lettuce Necrotic Yellow Virus Phosphoprotein C-Terminal Domain

Summary for 3T4R

• Entry DOI: 10.2210/pdb3t4r/pdb
• Descriptor: Phosphoprotein, MAGNESIUM ION (3 entities in total)
• Functional Keywords: helical bundle, nucleoprotein, viral protein
• Biological source: Lettuce necrotic yellows virus (LNYV)
• Cellular location: Virion: Q9E7N7
• Total number of polymer chains: 1
• Total formula weight: 9579.70

Authors

Martinez, N.,Tarbouriech, N.,Jamin, M. (deposition date: 2011-07-26, release date: 2013-01-30, Last modification date: 2024-10-09)

Primary citation

Martinez, N.,Ribeiro, E.A.,Leyrat, C.,Tarbouriech, N.,Ruigrok, R.W.,Jamin, M.
Structure of the C-terminal domain of lettuce necrotic yellows virus phosphoprotein.
J.Virol., 87:9569-9578, 2013

PubMed Abstract: Lettuce necrotic yellows virus (LNYV) is a prototype of the plant-adapted cytorhabdoviruses. Through a meta-prediction of disorder, we localized a folded C-terminal domain in the amino acid sequence of its phosphoprotein. This domain consists of an autonomous folding unit that is monomeric in solution. Its structure, solved by X-ray crystallography, reveals a lollipop-shaped structure comprising five helices. The structure is different from that of the corresponding domains of other Rhabdoviridae, Filoviridae, and Paramyxovirinae; only the overall topology of the polypeptide chain seems to be conserved, suggesting that this domain evolved under weak selective pressure and varied in size by the acquisition or loss of functional modules.

PubMed: 23785215
DOI: 10.1128/JVI.00999-13

Experimental method

X-RAY DIFFRACTION (2 Å)