3T4G

AIIGLMV segment from Alzheimer's Amyloid-Beta displayed on 54-membered macrocycle scaffold

3T4G の概要

• エントリーDOI: 10.2210/pdb3t4g/pdb
• 分子名称: Cyclic pseudo-peptide (ORN)AIIGLMV(ORN)KF(HAO)(4BF)K, (4S)-2-METHYL-2,4-PENTANEDIOL (2 entities in total)
• 機能のキーワード: amyloid-related, macrocycle, hao, unknown function
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 4212.94

構造登録者

Zhao, M.,Liu, C.,Cheng, P.N.,Eisenberg, D.,Nowick, J.S. (登録日: 2011-07-26, 公開日: 2012-10-31, 最終更新日: 2023-11-15)

• 主引用文献: Cheng, P.N.,Liu, C.,Zhao, M.,Eisenberg, D.,Nowick, J.S.; Amyloid beta-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity.; Nat Chem, 4:927-933, 2012; PubMed: 23089868; DOI: 10.1038/nchem.1433

実験手法

X-RAY DIFFRACTION (1.7 Å)