3T4A

Structure of a truncated form of Staphylococcal Complement Inhibitor B bound to human C3c at 3.4 Angstrom resolution

Summary for 3T4A

• Entry DOI: 10.2210/pdb3t4a/pdb
• Related: 3T46 3T47 3T48 3T49
• Descriptor: Complement C3 beta chain, Complement C3c alpha' chain fragment 1, Complement C3c alpha' chain fragment 2, ... (4 entities in total)
• Functional Keywords: age-related macular degeneration, cleavage on pair of basic residues, complement alternate pathway, complement pathway, disease mutation, disulfide bond, glycoprotein, hemolytic uremic syndrome, immunity, inflammatory response, innate immunity, phosphoprotein, secreted, thioester bond, immune system
• Biological source: Staphylococcus aureus subsp. aureus; More
• Cellular location: Secreted: P01024 P01024 P01024
• Total number of polymer chains: 8
• Total formula weight: 285532.87

Authors

Garcia, B.L.,Geisbrecht, B.V.,Summers, B.J. (deposition date: 2011-07-25, release date: 2011-11-23, Last modification date: 2023-09-13)

• Primary citation: Garcia, B.L.,Summers, B.J.,Lin, Z.,Ramyar, K.X.,Ricklin, D.,Kamath, D.V.,Fu, Z.Q.,Lambris, J.D.,Geisbrecht, B.V.; Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family.; J.Biol.Chem., 287:628-640, 2012; PubMed: 22086928; DOI: 10.1074/jbc.M111.298984

Experimental method

X-RAY DIFFRACTION (3.4 Å)