3T4A

Structure of a truncated form of Staphylococcal Complement Inhibitor B bound to human C3c at 3.4 Angstrom resolution

3T4A の概要

• エントリーDOI: 10.2210/pdb3t4a/pdb
• 関連するPDBエントリー: 3T46 3T47 3T48 3T49
• 分子名称: Complement C3 beta chain, Complement C3c alpha' chain fragment 1, Complement C3c alpha' chain fragment 2, ... (4 entities in total)
• 機能のキーワード: age-related macular degeneration, cleavage on pair of basic residues, complement alternate pathway, complement pathway, disease mutation, disulfide bond, glycoprotein, hemolytic uremic syndrome, immunity, inflammatory response, innate immunity, phosphoprotein, secreted, thioester bond, immune system
• 由来する生物種: Staphylococcus aureus subsp. aureus; 詳細
• 細胞内の位置: Secreted: P01024 P01024 P01024
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 285532.87

構造登録者

Garcia, B.L.,Geisbrecht, B.V.,Summers, B.J. (登録日: 2011-07-25, 公開日: 2011-11-23, 最終更新日: 2023-09-13)

• 主引用文献: Garcia, B.L.,Summers, B.J.,Lin, Z.,Ramyar, K.X.,Ricklin, D.,Kamath, D.V.,Fu, Z.Q.,Lambris, J.D.,Geisbrecht, B.V.; Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family.; J.Biol.Chem., 287:628-640, 2012; PubMed: 22086928; DOI: 10.1074/jbc.M111.298984

実験手法

X-RAY DIFFRACTION (3.4 Å)