A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS

Summary for 3T3M

Related3NID 3NIF 3NIG
DescriptorIntegrin alpha-IIb, Integrin beta-3, Monoclonal antibody 10E5 heavy chain, ... (12 entities in total)
Functional Keywordsintegrin, cell adhesion, blood clotting, fibrinogen, platelet
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P08514 P05106
Total number of polymer chains8
Total molecular weight302261.34
Zhu, J.,Zhu, J.,Springer, T.A. (deposition date: 2011-07-25, release date: 2012-03-28)
Primary citation
Zhu, J.,Choi, W.S.,McCoy, J.G.,Negri, A.,Zhu, J.,Naini, S.,Li, J.,Shen, M.,Huang, W.,Bougie, D.,Rasmussen, M.,Aster, R.,Thomas, C.J.,Filizola, M.,Springer, T.A.,Coller, B.S.
Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4:125ra32-125ra32, 2012
PubMed: 22422993 (PDB entries with the same primary citation)
DOI: 10.1126/scitranslmed.3003576
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21760.3%1.0%8.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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