3T3M
A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS
Summary for 3T3M
Entry DOI | 10.2210/pdb3t3m/pdb |
Related | 2VDR 3NID 3NIF 3NIG |
Descriptor | Integrin alpha-IIb, SULFATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total) |
Functional Keywords | integrin, cell adhesion, blood clotting, fibrinogen, platelet |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 302099.21 |
Authors | Zhu, J.,Zhu, J.,Springer, T.A. (deposition date: 2011-07-25, release date: 2012-03-28, Last modification date: 2023-11-29) |
Primary citation | Zhu, J.,Choi, W.S.,McCoy, J.G.,Negri, A.,Zhu, J.,Naini, S.,Li, J.,Shen, M.,Huang, W.,Bougie, D.,Rasmussen, M.,Aster, R.,Thomas, C.J.,Filizola, M.,Springer, T.A.,Coller, B.S. Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS Sci Transl Med, 4:125ra32-125ra32, 2012 Cited by PubMed: 22422993DOI: 10.1126/scitranslmed.3003576 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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