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3T3M

A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS

Summary for 3T3M
Entry DOI10.2210/pdb3t3m/pdb
Related2VDR 3NID 3NIF 3NIG
DescriptorIntegrin alpha-IIb, SULFATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (13 entities in total)
Functional Keywordsintegrin, cell adhesion, blood clotting, fibrinogen, platelet
Biological sourceHomo sapiens (human)
More
Total number of polymer chains8
Total formula weight302099.21
Authors
Zhu, J.,Zhu, J.,Springer, T.A. (deposition date: 2011-07-25, release date: 2012-03-28, Last modification date: 2023-11-29)
Primary citationZhu, J.,Choi, W.S.,McCoy, J.G.,Negri, A.,Zhu, J.,Naini, S.,Li, J.,Shen, M.,Huang, W.,Bougie, D.,Rasmussen, M.,Aster, R.,Thomas, C.J.,Filizola, M.,Springer, T.A.,Coller, B.S.
Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
Sci Transl Med, 4:125ra32-125ra32, 2012
Cited by
PubMed: 22422993
DOI: 10.1126/scitranslmed.3003576
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

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