3T3A

Crystal structure of H107R mutant of extracellular domain of mouse receptor NKR-P1A

3T3A の概要

• エントリーDOI: 10.2210/pdb3t3a/pdb
• 関連するPDBエントリー: 3M9Z
• 分子名称: Killer cell lectin-like receptor subfamily B member 1A, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: c-type lectin-like domain, domain swapping, twinning, natural killer cell receptor, transmembrane receptor, signaling protein
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Membrane; Single-pass type II membrane protein: P27811
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32340.55

構造登録者

Kolenko, P.,Rozbesky, D.,Bezouska, K.,Hasek, J.,Dohnalek, J. (登録日: 2011-07-25, 公開日: 2011-08-10, 最終更新日: 2024-11-06)

主引用文献

Kolenko, P.,Rozbesky, D.,Vanek, O.,Bezouska, K.,Hasek, J.,Dohnalek, J.
Structure of the H107R variant of the extracellular domain of mouse NKR-P1A at 2.3 A resolution.
Acta Crystallogr.,Sect.F, 67:1519-1523, 2011

PubMed Abstract: The structure of the H107R variant of the extracellular domain of the mouse natural killer cell receptor NKR-P1A has been determined by X-ray diffraction at 2.3 Å resolution from a merohedrally twinned crystal. Unlike the structure of the wild-type receptor in space group I4(1)22 with a single chain per asymmetric unit, the crystals of the variant belonged to space group I4(1) with a dimer in the asymmetric unit. Different degrees of merohedral twinning were detected in five data sets collected from different crystals. The mutation does not have a significant impact on the overall structure, but led to the binding of an additional phosphate ion at the interface of the molecules.

PubMed: 22139156
DOI: 10.1107/S1744309111046203

実験手法

X-RAY DIFFRACTION (2.3 Å)