3T0L
Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Summary for 3T0L
Entry DOI | 10.2210/pdb3t0l/pdb |
Related | 3LW1 3MHR 3T0M 3U9X 4DHM 4DHN 4DHO 4DHP 4DHQ 4DHR 4DHS 4DHT 4DHU |
Descriptor | 14-3-3 protein sigma, [2-(2-oxo-2-{[2-(trifluoromethyl)phenyl]amino}ethoxy)phenyl]phosphonic acid, GLYCEROL, ... (6 entities in total) |
Functional Keywords | helical protein, adapter protein, protein-protein interaction, protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P31947 |
Total number of polymer chains | 1 |
Total formula weight | 27200.26 |
Authors | Thiel, P.,Ottmann, C. (deposition date: 2011-07-20, release date: 2012-12-26, Last modification date: 2024-02-28) |
Primary citation | Thiel, P.,Roglin, L.,Meissner, N.,Hennig, S.,Kohlbacher, O.,Ottmann, C. Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49:8468-8470, 2013 Cited by PubMed: 23939230DOI: 10.1039/c3cc44612c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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