3SZN

Crystal structure of SARS coronavirus main protease complexed with an alpha, beta-unsaturated ethyl ester SG75

3SZN の概要

• エントリーDOI: 10.2210/pdb3szn/pdb
• 関連するPDBエントリー: 2h2z
• 分子名称: 3C-like proteinase, ETHYL (4R)-4-({N-[(BENZYLOXY)CARBONYL]-L-PHENYLALANYL}AMINO)-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE (3 entities in total)
• 機能のキーワード: sars coronavirus main protease, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: SARS coronavirus (SARS-CoV)
• 細胞内の位置: Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34386.23

構造登録者

Zhu, L.,Hilgenfeld, R. (登録日: 2011-07-19, 公開日: 2012-07-25, 最終更新日: 2017-11-08)

• 主引用文献: Zhu, L.,Hilgenfeld, R.; Crystal structures of SARS-Cov main protease complexed with a series of unsaturated esters; To be Published,

実験手法

X-RAY DIFFRACTION (1.69 Å)