3SYM

Glycogen Phosphorylase b in complex with 3 -C-(hydroxymethyl)-beta-D-glucopyranonucleoside of 5-fluorouracil

Summary for 3SYM

• Entry DOI: 10.2210/pdb3sym/pdb
• Related: 3SYR
• Descriptor: Glycogen phosphorylase, muscle form, 5-fluoro-1-[3-C-(hydroxymethyl)-beta-D-glucopyranosyl]pyrimidine-2,4(1H,3H)-dione (3 entities in total)
• Functional Keywords: alpha and beta protein, transferase-transferase inhibitor complex, muscle, transferase, glycogen metabolism, transferase/transferase inhibitor
• Biological source: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• Total number of polymer chains: 1
• Total formula weight: 97841.56

Authors

Skamnaki, V.T.,Katsandi, A.L.,Kontou, M.,Leonidas, D.D. (deposition date: 2011-07-18, release date: 2012-02-15, Last modification date: 2020-07-29)

• Primary citation: Manta, S.,Xipnitou, A.,Kiritsis, C.,Kantsadi, A.L.,Hayes, J.M.,Skamnaki, V.T.,Lamprakis, C.,Kontou, M.,Zoumpoulakis, P.,Zographos, S.E.,Leonidas, D.D.,Komiotis, D.; 3'-Axial CH(2) OH Substitution on Glucopyranose does not Increase Glycogen Phosphorylase Inhibitory Potency. QM/MM-PBSA Calculations Suggest Why.; Chem.Biol.Drug Des., 79:663-673, 2012; PubMed: 22296957; DOI: 10.1111/j.1747-0285.2012.01349.x

Experimental method

X-RAY DIFFRACTION (2.4 Å)