3SXF

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-89

3SXF の概要

• エントリーDOI: 10.2210/pdb3sxf/pdb
• 関連するPDBエントリー: 3I79 3I7B 3I7C 3MWU 3N51 3NCG 3NYV 3SX9 3T3U 3T3V
• 分子名称: Calmodulin-domain protein kinase 1, 3-(6-ethoxynaphthalen-2-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, DIMETHYL SULFOXIDE, ... (5 entities in total)
• 機能のキーワード: serine/threonine protein kinase, transferase, calcium-binding, atp-binding, calmodulin, ef hand, bumped kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Toxoplasma gondii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55714.53

構造登録者

Larson, E.T.,Merritt, E.A. (登録日: 2011-07-14, 公開日: 2012-03-14, 最終更新日: 2023-09-13)

• 主引用文献: Larson, E.T.,Ojo, K.K.,Murphy, R.C.,Johnson, S.M.,Zhang, Z.,Kim, J.E.,Leibly, D.J.,Fox, A.M.,Reid, M.C.,Dale, E.J.,Perera, B.G.,Kim, J.,Hewitt, S.N.,Hol, W.G.,Verlinde, C.L.,Fan, E.,Van Voorhis, W.C.,Maly, D.J.,Merritt, E.A.; Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.; J.Med.Chem., 55:2803-2810, 2012; PubMed: 22369268; DOI: 10.1021/jm201725v

実験手法

X-RAY DIFFRACTION (2.04 Å)