3SX9
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-132
Summary for 3SX9
Entry DOI | 10.2210/pdb3sx9/pdb |
Related | 3I79 3I7B 3I7C 3MWU 3N51 3NCG 3NYV 3SXF 3T3U 3T3V |
Descriptor | Calmodulin-domain protein kinase 1, 3-(6-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total) |
Functional Keywords | serine/threonine protein kinase, transferase, calcium-binding, atp-binding, calmodulin, ef hand, bumped kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Toxoplasma gondii |
Total number of polymer chains | 1 |
Total formula weight | 55629.41 |
Authors | Larson, E.T.,Merritt, E.A. (deposition date: 2011-07-14, release date: 2012-03-14, Last modification date: 2023-09-13) |
Primary citation | Larson, E.T.,Ojo, K.K.,Murphy, R.C.,Johnson, S.M.,Zhang, Z.,Kim, J.E.,Leibly, D.J.,Fox, A.M.,Reid, M.C.,Dale, E.J.,Perera, B.G.,Kim, J.,Hewitt, S.N.,Hol, W.G.,Verlinde, C.L.,Fan, E.,Van Voorhis, W.C.,Maly, D.J.,Merritt, E.A. Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J.Med.Chem., 55:2803-2810, 2012 Cited by PubMed: 22369268DOI: 10.1021/jm201725v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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