3SUB

Crystal structure of the catalytic domain of Plasmodium falciparum ARF GTPase activating protein

3SUB の概要

• エントリーDOI: 10.2210/pdb3sub/pdb
• 分子名称: ADP-ribosylation factor GTPase-activating protein, ZINC ION, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: gtpase-activating protein, protein trafficking, hydrolase activator
• 由来する生物種: Plasmodium falciparum 3D7
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37558.74

構造登録者

Cook, W.J.,Chattopadhyay, D. (登録日: 2011-07-11, 公開日: 2011-11-09, 最終更新日: 2024-02-28)

主引用文献

Cook, W.J.,Senkovich, O.,Chattopadhyay, D.
Structure of the catalytic domain of Plasmodium falciparum ARF GTPase-activating protein (ARFGAP).
Acta Crystallogr.,Sect.F, 67:1339-1344, 2011

PubMed Abstract: The crystal structure of the catalytic domain of the ADP ribosylation factor GTPase-activating protein (ARFGAP) from Plasmodium falciparum has been determined and refined to 2.4 Å resolution. Multiwavength anomalous diffraction (MAD) data were collected utilizing the Zn(2+) ion bound at the zinc-finger domain and were used to solve the structure. The overall structure of the domain is similar to those of mammalian ARFGAPs. However, several amino-acid residues in the area where GAP interacts with ARF1 differ in P. falciparum ARFGAP. Moreover, a number of residues that form the dimer interface in the crystal structure are unique in P. falciparum ARFGAP.

PubMed: 22102228
DOI: 10.1107/S1744309111032507

実験手法

X-RAY DIFFRACTION (2.4 Å)