3STO

Serpin from the trematode Schistosoma Haematobium

3STO の概要

• エントリーDOI: 10.2210/pdb3sto/pdb
• 分子名称: Serine protease inhibitor (2 entities in total)
• 機能のキーワード: serpin fold, protease inhibitor, hydrolase inhibitor
• 由来する生物種: Schistosoma haematobium (Blood fluke)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46349.53

構造登録者

Granzin, J.,Weiergraeber, O.H.,Lee, X.,Blanton, R.E. (登録日: 2011-07-11, 公開日: 2012-05-30, 最終更新日: 2024-11-06)

主引用文献

Granzin, J.,Huang, Y.,Topbas, C.,Huang, W.,Wu, Z.,Misra, S.,Hazen, S.L.,Blanton, R.E.,Lee, X.,Weiergraber, O.H.
Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain.
Acta Crystallogr.,Sect.D, 68:686-694, 2012

PubMed Abstract: Parasitic organisms are constantly challenged by the defence mechanisms of their respective hosts, which often depend on serine protease activities. Consequently, protease inhibitors such as those belonging to the serpin superfamily have emerged as protective elements that support the survival of the parasites. This report describes the crystal structure of ShSPI, a serpin from the trematode Schistosoma haematobium. The protein is exposed on the surface of invading cercaria as well as of adult worms, suggesting its involvement in the parasite-host interaction. While generally conforming to the well established serpin fold, the structure reveals several distinctive features, mostly concerning the helical subdomain of the protein. It is proposed that these peculiarities are related to the unique biological properties of a small serpin subfamily which is conserved among pathogenic schistosomes.

PubMed: 22683791
DOI: 10.1107/S0907444912008372

実験手法

X-RAY DIFFRACTION (2.41 Å)