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3SOV

The structure of a beta propeller domain in complex with peptide S

3SOV の概要
エントリーDOI10.2210/pdb3sov/pdb
関連するPDBエントリー3SOB 3SOQ
分子名称Low-density lipoprotein receptor-related protein 6, Sclerostin, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
機能のキーワードbeta propeller, protein binding-antagonist complex, protein binding/antagonist
由来する生物種Homo sapiens (human)
詳細
タンパク質・核酸の鎖数2
化学式量合計37826.17
構造登録者
Wang, W.,Bourhis, E.,Zhang, Y.,Rouge, L.,Wu, Y.,Franke, Y.,Cochran, A.G. (登録日: 2011-06-30, 公開日: 2011-09-21, 最終更新日: 2024-10-16)
主引用文献Bourhis, E.,Wang, W.,Tam, C.,Hwang, J.,Zhang, Y.,Spittler, D.,Huang, O.W.,Gong, Y.,Estevez, A.,Zilberleyb, I.,Rouge, L.,Chiu, C.,Wu, Y.,Costa, M.,Hannoush, R.N.,Franke, Y.,Cochran, A.G.
Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
Structure, 19:1433-1442, 2011
Cited by
PubMed Abstract: The Wnt pathway inhibitors DKK1 and sclerostin (SOST) are important therapeutic targets in diseases involving bone loss or damage. It has been appreciated that Wnt coreceptors LRP5/6 are also important, as human missense mutations that result in bone overgrowth (bone mineral density, or BMD, mutations) cluster to the E1 propeller domain of LRP5. Here, we report a crystal structure of LRP6 E1 bound to an antibody, revealing that the E1 domain is a peptide recognition module. Remarkably, the consensus E1 binding sequence is a close match to a conserved tripeptide motif present in all Wnt inhibitors that bind LRP5/6. We show that this motif is important for DKK1 and SOST binding to LRP6 and for inhibitory function, providing a detailed structural explanation for the effect of the BMD mutations.
PubMed: 21944579
DOI: 10.1016/j.str.2011.07.005
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.27 Å)
構造検証レポート
Validation report summary of 3sov
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-07-16に公開中

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