3SOV
The structure of a beta propeller domain in complex with peptide S
3SOV の概要
エントリーDOI | 10.2210/pdb3sov/pdb |
関連するPDBエントリー | 3SOB 3SOQ |
分子名称 | Low-density lipoprotein receptor-related protein 6, Sclerostin, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
機能のキーワード | beta propeller, protein binding-antagonist complex, protein binding/antagonist |
由来する生物種 | Homo sapiens (human) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 37826.17 |
構造登録者 | Wang, W.,Bourhis, E.,Zhang, Y.,Rouge, L.,Wu, Y.,Franke, Y.,Cochran, A.G. (登録日: 2011-06-30, 公開日: 2011-09-21, 最終更新日: 2024-10-16) |
主引用文献 | Bourhis, E.,Wang, W.,Tam, C.,Hwang, J.,Zhang, Y.,Spittler, D.,Huang, O.W.,Gong, Y.,Estevez, A.,Zilberleyb, I.,Rouge, L.,Chiu, C.,Wu, Y.,Costa, M.,Hannoush, R.N.,Franke, Y.,Cochran, A.G. Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6. Structure, 19:1433-1442, 2011 Cited by PubMed Abstract: The Wnt pathway inhibitors DKK1 and sclerostin (SOST) are important therapeutic targets in diseases involving bone loss or damage. It has been appreciated that Wnt coreceptors LRP5/6 are also important, as human missense mutations that result in bone overgrowth (bone mineral density, or BMD, mutations) cluster to the E1 propeller domain of LRP5. Here, we report a crystal structure of LRP6 E1 bound to an antibody, revealing that the E1 domain is a peptide recognition module. Remarkably, the consensus E1 binding sequence is a close match to a conserved tripeptide motif present in all Wnt inhibitors that bind LRP5/6. We show that this motif is important for DKK1 and SOST binding to LRP6 and for inhibitory function, providing a detailed structural explanation for the effect of the BMD mutations. PubMed: 21944579DOI: 10.1016/j.str.2011.07.005 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.27 Å) |
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