3SKC

Human B-Raf Kinase in Complex with an Amide Linked Pyrazolopyridine Inhibitor

Summary for 3SKC

• Entry DOI: 10.2210/pdb3skc/pdb
• Descriptor: Serine/threonine-protein kinase B-raf, 2,6-difluoro-N-[(5S)-3-methoxy-5H-pyrazolo[3,4-b]pyridin-5-yl]-3-[(phenylsulfonyl)amino]benzamide (2 entities in total)
• Functional Keywords: kinase, atp-competitive inhibitor, transferase, ras, mek, c-raf, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus (By similarity): P15056
• Total number of polymer chains: 2
• Total formula weight: 71354.12

Authors

Voegtli, W.C.,Sturgis, H.L. (deposition date: 2011-06-22, release date: 2011-08-17, Last modification date: 2024-02-28)

• Primary citation: Wenglowsky, S.,Ahrendt, K.A.,Buckmelter, A.J.,Feng, B.,Gloor, S.L.,Gradl, S.,Grina, J.,Hansen, J.D.,Laird, E.R.,Lunghofer, P.,Mathieu, S.,Moreno, D.,Newhouse, B.,Ren, L.,Risom, T.,Rudolph, J.,Seo, J.,Sturgis, H.L.,Voegtli, W.C.,Wen, Z.; Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships.; Bioorg.Med.Chem.Lett., 21:5533-5537, 2011; PubMed: 21802293; DOI: 10.1016/j.bmcl.2011.06.097

Experimental method

X-RAY DIFFRACTION (3.2 Å)