3SJO
structure of EV71 3C in complex with Rupintrivir (AG7088)
Summary for 3SJO
Entry DOI | 10.2210/pdb3sjo/pdb |
Related | 1CQQ 1L1N 2ZTY 3SJ8 3SJ9 3SJI 3SJK |
Descriptor | 3C protease, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER (3 entities in total) |
Functional Keywords | in complex with rupintrivir, chymotrypsin-like fold, protease, c147 covalently binds to rupintrivir, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human enterovirus 71 |
Total number of polymer chains | 8 |
Total formula weight | 173999.10 |
Authors | |
Primary citation | Lu, G.,Qi, J.,Chen, Z.,Xu, X.,Gao, F.,Lin, D.,Qian, W.,Liu, H.,Jiang, H.,Yan, J.,Gao, G.F. Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design. J.Virol., 85:10319-10331, 2011 Cited by PubMed: 21795339DOI: 10.1128/JVI.00787-11 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.702 Å) |
Structure validation
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