3SI2

Structure of glycosylated murine glutaminyl cyclase in presence of the inhibitor PQ50 (PDBD150)

Summary for 3SI2

Entry DOI	10.2210/pdb3si2/pdb
Related	3SI0 3SI1
Related PRD ID	PRD_900017
Descriptor	Glutaminyl-peptide cyclotransferase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (7 entities in total)
Functional Keywords	alpha/beta hydrolase, alzheimer's disease, pyroglutamate, pglu, pe, pglu-amyloid, glycosylation, glycoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mus musculus (mouse)
Total number of polymer chains	1
Total formula weight	38746.00
Authors	Parthier, C.,Carrillo, D.,Stubbs, M.T. (deposition date: 2011-06-17, release date: 2011-06-29, Last modification date: 2023-09-13)
Primary citation	Ruiz-Carrillo, D.,Koch, B.,Parthier, C.,Wermann, M.,Dambe, T.,Buchholz, M.,Ludwig, H.H.,Heiser, U.,Rahfeld, J.U.,Stubbs, M.T.,Schilling, S.,Demuth, H.U. Structures of Glycosylated Mammalian Glutaminyl Cyclases Reveal Conformational Variability near the Active Center. Biochemistry, 50:6280-6288, 2011 Cited by PubMed: 21671571 DOI: 10.1021/bi200249h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation