Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3SHY

Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors

Summary for 3SHY
Entry DOI10.2210/pdb3shy/pdb
Related1T9R 3SHZ 3SIE
DescriptorcGMP-specific 3',5'-cyclic phosphodiesterase, 6-ethyl-5-fluoro-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, ZINC ION, ... (5 entities in total)
Functional Keywordspde5a inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight40667.93
Authors
Chen, T.T.,Chen, T.,Xu, Y.C. (deposition date: 2011-06-17, release date: 2011-08-24, Last modification date: 2024-03-20)
Primary citationXu, Z.,Liu, Z.,Chen, T.,Chen, T.T.,Wang, Z.,Tian, G.,Shi, J.,Wang, X.,Lu, Y.,Yan, X.,Wang, G.,Jiang, H.,Chen, K.,Wang, S.,Xu, Y.,Shen, J.,Zhu, W.
Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors.
J.Med.Chem., 54:5607-5611, 2011
Cited by
PubMed: 21714539
DOI: 10.1021/jm200644r
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.647 Å)
Structure validation

217705

건을2024-03-27부터공개중

PDB statisticsPDBj update infoContact PDBjnumon