3SGT

Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1299

Summary for 3SGT

Entry DOI	10.2210/pdb3sgt/pdb
Descriptor	Undecaprenyl pyrophosphate synthase, 2-{[4-(3,4-dimethylphenoxy)phenyl]carbamoyl}benzoic acid (3 entities in total)
Functional Keywords	alpha/beta, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Escherichia coli O6
Total number of polymer chains	2
Total formula weight	57323.65
Authors	Cao, R.,Liu, Y.-L.,Oldfield, E. (deposition date: 2011-06-15, release date: 2012-12-19, Last modification date: 2023-09-13)
Primary citation	Zhu, W.,Zhang, Y.,Sinko, W.,Hensler, M.E.,Olson, J.,Molohon, K.J.,Lindert, S.,Cao, R.,Li, K.,Wang, K.,Wang, Y.,Liu, Y.L.,Sankovsky, A.,de Oliveira, C.A.,Mitchell, D.A.,Nizet, V.,McCammon, J.A.,Oldfield, E. Antibacterial drug leads targeting isoprenoid biosynthesis. Proc.Natl.Acad.Sci.USA, 110:123-128, 2013 Cited by PubMed: 23248302 DOI: 10.1073/pnas.1219899110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation