3SC8

Crystal structure of an intramolecular human telomeric DNA G-quadruplex bound by the naphthalene diimide BMSG-SH-3

3SC8 の概要

• エントリーDOI: 10.2210/pdb3sc8/pdb
• 分子名称: Human telomeric repeat sequence, POTASSIUM ION, 2,7-bis[3-(4-methylpiperazin-1-yl)propyl]-4,9-bis{[3-(4-methylpiperazin-1-yl)propyl]amino}benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone, ... (4 entities in total)
• 機能のキーワード: g-quadruplex, intramolecular, ligand-complex, telomeric, dna
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7957.93

構造登録者

Collie, G.W.,Promontorio, R.,Parkinson, G.N. (登録日: 2011-06-07, 公開日: 2012-02-15, 最終更新日: 2023-09-13)

• 主引用文献: Collie, G.W.,Promontorio, R.,Hampel, S.M.,Micco, M.,Neidle, S.,Parkinson, G.N.; Structural basis for telomeric g-quadruplex targeting by naphthalene diimide ligands.; J.Am.Chem.Soc., 134:2723-2731, 2012; PubMed: 22280460; DOI: 10.1021/ja2102423

実験手法

X-RAY DIFFRACTION (2.302 Å)