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3S92

Crystal Structure of the second bromodomain of human BRD3 in complex with the inhibitor JQ1

Summary for 3S92
Entry DOI10.2210/pdb3s92/pdb
Related3S91
DescriptorBromodomain-containing protein 3, (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsbrd3, bromodomain containing protein 3, orfx, ring3 like gene, ring3l, jq1, structural genomics, structural genomics consortium, sgc, unknown function
Biological sourceHomo sapiens (human)
Cellular locationNucleus (Potential): Q15059
Total number of polymer chains1
Total formula weight13827.46
Authors
Primary citationFilippakopoulos, P.,Picaud, S.,Qi, J.,Keates, T.,Felletar, I.,Fedorov, O.,Muniz, J.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Bradner, J.E.,Knapp, S.
Crystal Structure of the second bromodomain of human BRD3 in complex with the inhibitor JQ1
To be Published,
Experimental method
X-RAY DIFFRACTION (1.36 Å)
Structure validation

217705

数据于2024-03-27公开中

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