3S7L
Pyrazolyl and Thienyl Aminohydantoins as Potent BACE1 Inhibitors
Summary for 3S7L
Entry DOI | 10.2210/pdb3s7l/pdb |
Related | 3S7M |
Descriptor | Beta-secretase 1, (5S)-2-amino-5-(1-ethyl-1H-pyrazol-4-yl)-3-methyl-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one (3 entities in total) |
Functional Keywords | aspartyl protease, disulfide bond, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 46802.38 |
Authors | |
Primary citation | Malamas, M.S.,Erdei, J.,Gunawan, I.,Barnes, K.,Hui, Y.,Johnson, M.,Robichaud, A.,Zhou, P.,Yan, Y.,Solvibile, W.,Turner, J.,Fan, K.Y.,Chopra, R.,Bard, J.,Pangalos, M.N. New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2' region. Bioorg.Med.Chem.Lett., 21:5164-5170, 2011 Cited by PubMed: 21835615DOI: 10.1016/j.bmcl.2011.07.057 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.162 Å) |
Structure validation
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