3S4Q

P38 alpha kinase complexed with a pyrazolo-triazine based inhibitor

3S4Q の概要

• エントリーDOI: 10.2210/pdb3s4q/pdb
• 分子名称: Mitogen-activated protein kinase 14, 3-[(6-benzoyl-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]-N-cyclopropyl-4-methylbenzamide (3 entities in total)
• 機能のキーワード: p38 map kinase, serine/threonine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42530.49

構造登録者

Sack, J.S. (登録日: 2011-05-20, 公開日: 2012-02-01, 最終更新日: 2024-02-28)

• 主引用文献: Dyckman, A.J.,Li, T.,Pitt, S.,Zhang, R.,Shen, D.R.,McIntyre, K.W.,Gillooly, K.M.,Shuster, D.J.,Doweyko, A.M.,Sack, J.S.,Kish, K.,Kiefer, S.E.,Newitt, J.A.,Zhang, H.,Marathe, P.H.,McKinnon, M.,Barrish, J.C.,Dodd, J.H.,Schieven, G.L.,Leftheris, K.; Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.; Bioorg.Med.Chem.Lett., 21:4633-4637, 2011; PubMed: 21705217; DOI: 10.1016/j.bmcl.2011.05.091

実験手法

X-RAY DIFFRACTION (2.27 Å)