3S4P
Crystal structure of the bacterial ribosomal decoding site complexed with an amphiphilic paromomycin O2''-ether analogue
Summary for 3S4P
Entry DOI | 10.2210/pdb3s4p/pdb |
Related | 2BE0 2BEE 2PWT |
Descriptor | RNA (5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'), (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-2-O-{2-[(2-phenylethyl)amino]ethyl}-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside (3 entities in total) |
Functional Keywords | aminoglycoside, antibiotics, ribosome, decoding site, rna, rna-antibiotic complex, rna/antibiotic |
Total number of polymer chains | 2 |
Total formula weight | 15011.84 |
Authors | Szychowski, J.,Kondo, J.,Zahr, O.,Auclair, K.,Westhof, E.,Hanessian, S.,Keillor, J.W. (deposition date: 2011-05-20, release date: 2011-09-21, Last modification date: 2023-11-01) |
Primary citation | Szychowski, J.,Kondo, J.,Zahr, O.,Auclair, K.,Westhof, E.,Hanessian, S.,Keillor, J.W. Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues Chemmedchem, 6:1961-1966, 2011 Cited by PubMed: 21905229DOI: 10.1002/cmdc.201100346 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.56 Å) |
Structure validation
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