3S4P

Crystal structure of the bacterial ribosomal decoding site complexed with an amphiphilic paromomycin O2''-ether analogue

Summary for 3S4P

• Entry DOI: 10.2210/pdb3s4p/pdb
• Related: 2BE0 2BEE 2PWT
• Descriptor: RNA (5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3'), (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-2-O-{2-[(2-phenylethyl)amino]ethyl}-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside (3 entities in total)
• Functional Keywords: aminoglycoside, antibiotics, ribosome, decoding site, rna, rna-antibiotic complex, rna/antibiotic
• Total number of polymer chains: 2
• Total formula weight: 15011.84

Authors

Szychowski, J.,Kondo, J.,Zahr, O.,Auclair, K.,Westhof, E.,Hanessian, S.,Keillor, J.W. (deposition date: 2011-05-20, release date: 2011-09-21, Last modification date: 2023-11-01)

• Primary citation: Szychowski, J.,Kondo, J.,Zahr, O.,Auclair, K.,Westhof, E.,Hanessian, S.,Keillor, J.W.; Inhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues; Chemmedchem, 6:1961-1966, 2011; PubMed: 21905229; DOI: 10.1002/cmdc.201100346

Experimental method

X-RAY DIFFRACTION (2.56 Å)